Penny and Beverly (Leonard’s Mom) are doing shots at a bar in episode 3x11, “The Maternal Congruence,” of The Big Bang Theory.
Penny: Now this time try drinking it all at once.
Beverly: *does shot* Ah! Yikes!
Penny: I’ve been responsible for my own buzz since 2003. *calls to the bartender* Another round for me and my homegirl!
Beverly: I feel a spreading warmth through my extremities. [I must be experiencing ethanol-induced vasodilation, resulting in an increased rate of blood flow raising my peripheral skin temperatures. Fascinating.]
Penny: As long as you don’t feel it running down your pants you’re fine.
Penny and Beverly clink glasses.
Captain Obvious: [text] = what I expected her to add. =/